Berberine CoQ10 combines two powerful nutrients that have been studied for their potential health benefits. Berberine, a plant extract, has been researched for its role in promoting healthy cholesterol and blood sugar levels already in the normal range. CoQ10 is an important compound found naturally in the body that provides antioxidant support and supports cellular energy production.*

While individual results may vary, many report feeling more energized after taking Berberine CoQ10. As with any supplement, we recommend consulting your healthcare provider before use, especially if you have any existing conditions.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Phytosome is a type of dietary supplement that uses a unique delivery system to enhance the bioavailability of phytochemicals, which are naturally-occurring compounds found in plants. The phytosome delivery system typically involves combining a phytochemical with a phospholipid, which can help to improve the absorption and effectiveness of the phytochemical. Some potential benefits of phytosomes include improved nutrient absorption, increased antioxidant activity, and reduced inflammation.

Phytosomes were found to improve solubility, permeability rate and bioavailability of active compounds in various cases (Jain et al., 2010) and inhibit or delay physical and chemical degradation and could be implemented without generating any toxic effects (Karimi et al., 2015).

Other advantages of phytosomes are that they protect active ingredient from destruction from gastric juices and gut bacteria. Besides acting as a carrier for polar compounds, phosphatidylcholine has also hepatoprotective effect (Semalty, Semalty, & Rawat, 2007).

Phytosomes are a new type of herbal extract formulations providing better absorption and enhanced bioavailability in comparison with standard plant extracts (Acharya et al., 2011; Karimi et al., 2015).

Phytosomes are delivery systems that are structurally related to liposomes (Ting et al., 2014). Phytosomes are prepared through the attachment of individual ingredients of herbal extracts to phosphatidyl choline, resulting in a formulation having higher solubility and hence better absorption leading to promoted pharmacokinetic and pharmacodynamic properties compared to the conventional herbal extracts (Ajazuddin and Saraf, 2010).

Although liposomes and phytosomes have some similarities, there are differences between them in term of chemical structure. ...There differences result in phytosomes to have much better absorption and more bioavailability than liposomes (Babazadeh et al., 2018; Semalty et al., 2010).

Source:

https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/phytosome

Berbevis® 1,100mg (275mgx4capsules daily), made with advanced and natural phytosome technology, has more than 10 times higher bioavailability, When compared to 1,500mg of pure Berberine.

Clinical Trial

Nutrients

2021 Oct 19;13(10):3665.

doi: 10.3390/nu13103665.

Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome: A One-Group Pretest-Post-Test Explanatory Study

Mariangela Rondanelli 1 2, Antonella Riva 3, Giovanna Petrangolini 3, Pietro Allegrini 3, Attilio Giacosa 4, Teresa Fazia 5, Luisa Bernardinelli 5, Clara Gasparri 6, Gabriella Peroni 6, Simone Perna 7
Affiliations expand

• PMID: 34684666
• PMCID: PMC8538182
• DOI: 10.3390/nu13103665

Free PMC article

Abstract
Polycystic Ovary Syndrome (PCOS) is the most frequent endocrine disease in females of reproductive age and is characterized by multifactorial unhealthy conditions related to hormonal unbalance and also to dysmetabolism and inflammation. Recently, increasing evidence has shown that natural plant-based products may play a role in PCOS management. The aim of this one-group pretest-post-test explanatory study was to evaluate, in normal-overweight PCOS women with normal menses, the effectiveness of berberine on: Insulin resistance (IR) by Homeostasis Model Assessment (HOMA); Inflammation by C-Reactive Protein (CRP), Tumor Necrosis Factor α (TNF-α); Lipid metabolism; Sex hormone profile and symptoms correlated to hyperandrogenism, such as acne, by Global Acne Grading System (GAGS) and Cardiff Acne Disability Index (CADI); Body composition by DXA. Finally, adverse effects were assessed by liver and kidney functions and creatine phosphokinase (CPK). All these parameters were collected at baseline and 60 days after supplementation with a new bioavailable and safe berberine formulation. Twelve females (aged 26.6 ± 4.9, BMI 25.3 ± 3.6) were supplied for 60 days with two tablets/day (550 mg/table) of the bioavailable berberine. Results showed a statistically significant decrease in HOMA, CRP, TNF-α, Triglycerides, testosterone, Body Mass Index (BMI), Visceral Adipose Tissue (VAT), fat mass, GAGS and CADI scores, and a statistically significant increase in sex hormone-binding globulin (SHBG). Liver and kidney functions and CPK are not statistically significantly different. Therefore, berberine can represent a safe novel dietary supplement, helpful in treatment strategy for PCOS.
Keywords: acne symptoms; berberine; homeostasis model assessment; inflammation; phytosome; polycystic ovary syndrome; visceral adipose tissue.

Conflict of interest statement
The authors declare no conflict of interest.

Figures

https://pubmed.ncbi.nlm.nih.gov/

Clinical Trial
Adv Ther

2015 Jul;32(7):680-90.
doi: 10.1007/s12325-015-0229-x. Epub 2015 Jul 23.
Nutraceuticals for Serum Lipid and Blood Pressure Control in Hypertensive and Hypercholesterolemic Subjects at Low Cardiovascular Risk
Alberto Mazza 1, Salvatore Lenti, Laura Schiavon, Marco Zuin, Maria D'Avino, Emilio Ramazzina, Edoardo Casiglia
Affiliations expand

• PMID: 26202829
• DOI: 10.1007/s12325-015-0229-x

Abstract
Introduction: Primary cardiovascular (CV) prevention may be achieved by lifestyle/nutrition changes, although a relevant role is now emerging for specific, functional foods and nutraceutical compounds (NCs). The aim of this study was to investigate the efficacy and safety of NCs in lowering blood pressure (BP) and improving lipid profile, when added to diet and lifestyle management versus diet alone in a group of patients with hypertension (HT) and hypercholesterolemia (HCh) with low CV risk.
Methods: Sixty-six patients with HT and HCh with grade 1 essential HT (mean age 56.0 ± 4.6 years) without history of CV diseases or organ damage were analyzed. These subjects were started on one tablet of an NC-containing red yeast rice, policosanol, berberine, folic acid and coenzyme Q10 once daily for 6 months and were age and gender matched with subjects following a diet program. Differences in clinic BP, 24-h ambulatory BP (24 h-ABPM), serum total cholesterol, low-density and high-density lipoprotein cholesterol (LDL-C and HDL-C) and triglyceride values were compared by analysis of variance.
Results: In the treatment group, a significant reduction of systolic 24 h-ABPM (141.6 ± 6.4 vs. 136.2 ± 4.8 mmHg; p < 0.05) and pulse pressure 24 h-ABPM (52.6 ± 7.2 vs. 47.3 ± 5.4 mmHg; p < 0.05) was found at the end of follow-up. A reduction of total cholesterol (-19.2%), LDL-C (-17.4%) and triglycerides (-16.3%) was observed (p < 0.001 for all); HDL-C remained unchanged. No difference was found in the control group.
Conclusions: The tested NCs was found to be safe, well tolerated and effective in reducing mean 24-h systolic and 24-h pulse pressure and in improving lipid pattern.

https://pubmed.ncbi.nlm.nih.gov/

Berberine Aristata is a natural plant alkaloid substance that grows in India and China, that has been used for more than 3000 years in Indian Ayurveda and Chinese traditional medicine. It is extracted from the bark, stems, roots of plum trees, yellow lotus, yellow wall trees, and long-horned grapes. It is evaluated as a much more powerful substance than the anti-inflammatory & anti-aging effects of curcumin and quercetin.

For best results, take four capsules of Berberine CoQ10 daily, either all at once or split into two doses of two capsules each. We recommend taking the capsules with a meal to enhance absorption and reduce the risk of digestive discomfort. Follow the recommended dosage and consult your healthcare provider before starting Berberine CoQ10, especially if you have any pre-existing health conditions, are pregnant, nursing, or taking medications.

Most people tolerate Berberine CoQ10 well, but some may experience minor side effects such as digestive discomfort or allergic reactions. If you have concerns about side effects, consult a healthcare professional.

Yes, Berberine CoQ10 is suitable for vegetarians. All ingredients are vegetarian-friendly. Check the product label for specific dietary compatibility.

Expecting a new bundle of joy? Or navigating the beautiful journey of breastfeeding? We understand how important it is to prioritize your health and that of your little one during this delicate time. That's why we recommend consulting with your healthcare provider before introducing any new supplement, including Berberine CoQ10, into your routine. They'll be able to guide you on the best course of action based on your specific circumstances.

We know how tricky it can be to juggle multiple supplements and medications. That's why we always advise checking in with your healthcare professional before adding Berberine CoQ10 to the mix. They'll be able to evaluate any potential interactions with other medications you're taking and ensure it's a safe addition to your wellness routine.

At NUTOBE, we take quality seriously. That's why our Berberine CoQ10 is manufactured right here in the USA, in facilities that meet the highest FDA standards. From ingredient sourcing to production, every step is meticulously monitored to ensure you're getting a premium product you can trust.

When it comes to your wellness, we believe in going the extra mile. That's why our Berberine CoQ10 has received GMP (Good Manufacturing Practices) certification, ensuring it's produced under the strictest quality control guidelines. But we didn't stop there – it's also regularly tested by third-party labs to verify purity and safety, giving you peace of mind with every capsule.

To keep your Berberine CoQ10 in tip-top shape, simply store it in a cool, dry place away from direct sunlight. Easy peasy! And for best results, be sure to follow any specific storage instructions on the product label.

At NUTOBE, your satisfaction is our top priority. That's why we offer a hassle-free 30-day refund policy on all purchases made directly through our official website. If for any reason you're not completely satisfied with your Berberine CoQ10, simply reach out to our friendly customer service team, and they'll guide you through the easy refund process. Your wellness journey should be worry-free, and we're here to support you every step of the way.

Great question! We know how exciting it is to get your hands on a new wellness solution. Shipping fees for Berberine CoQ10 purchases are calculated based on your location and preferred shipping option. Don't worry – you'll be able to review the costs during checkout, so there are no surprises. And just for your reference, all orders are shipped directly from our facility in sunny Los Angeles.

While we strive to provide accurate and helpful information about our product, it's important to note that the statements made about Berberine CoQ10 have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease. The information provided is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or your health goals before using any supplement.

Individual results may vary. The benefits and potential effects described are based on general knowledge of the ingredients and may not apply to everyone. If you have any concerns or pre-existing health conditions, we recommend consulting with a healthcare professional before starting any new supplement regimen.

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Berberine CoQ10 Instagram Review Event

Share your journey with our innovative Berberine CoQ10 supplement and be rewarded! From March 25th to May 30th, upload your product unboxing and 30-day review videos on Instagram, follow @nutobe_my, use #NUTOBE #berberineCoQ10 #instagramevent, and leave a 'participation complete' comment. 50 lucky winners will receive our highly anticipated second product as a gift when it launches!